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Invitrogen™ Human ZNF350 Synthetic Peptide
Synthetic Peptide
Brand: Invitrogen™ PEP0734
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Description
ZBRK1 Synthetic Peptide, PEP-0734, from Invitrogen.
ZBRK1 is a member of the Kruppel-associated box-zinc finger protein (KRAB-ZFP) protein family of transcriptional repressors. ZBRK1 has been shown to not only be up-regulated in senescent fibroblasts but also interacts with BRCA1, a transcriptional regulator with tumor suppressor activity. ZBRK1 binds to a specific sequence within the GADD45 gene, supporting the assembly of a nuclear complex containing BRCA1 and repressing its transcription. Recent experiments demonstrate that ZBRK1 can homo-oligomerize in vitro and in vivo through a C-terminal transcriptional repression domain (CTRD), and this oligomerization facilitates the ZBRK1-directed transcriptional repression through ZBRK1 response elements. These results suggest that higher order ZBRK1 oligomers may assemble through both protein-DNA and CTRD-dependent protein-protein interactions.
Specifications
| 59348 | |
| purified | |
| Human ZNF350 | |
| -20°C | |
| Liquid | |
| Blocking Assay, Control | |
| No | |
| Peptide | |
| RUO - research use only |
| Human | |
| Q9GZX5 | |
| 200 μg/mL | |
| Synthetic Peptide | |
| PBS with 0.1% BSA and 0.02% sodium azide; pH 7.2 | |
| ZNF350 | |
| 0.02% sodium azide | |
| 50 μg | |
| PBS |
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