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Thermo Scientific Chemicals SP600125, 98%
CAS: 129-56-6 | C14H8N2O, C14H8N2O | 220.23 g/mol
Brand: Thermo Scientific Chemicals J67272.MC
| Quantity | 100 mg |
|---|
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Description
SP 600125 is a potent and reversible inhibitor of JNK1-3 with an IC50 value of 0.11 M.1 It is cell-permeable and dose-dependently inhibits c-Jun phosphorylation in cells, blocking the expression of COX-2 and TNF-α in monocytes and IL-10, TNF-α, and IFN-γ in T-cells. SP 600125 also prevents apoptosis in many cell types, including B-cells, and inhibits autophagy in HeLa cells. Competitively and reversibly inhibits JNK1, 2 and 3 (IC50 = 40 - 90 nM) with negligible activity at ERK2, p38β and a range of enzymes (IC50 > 10 ?M). Shown to have reduced selectivity over other protein kinases under certain conditions. Prevents BMP9-induced osteogenic differentiation of MSCs.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Chemical Identifiers
| 129-56-6 | |
| C14H8N2O | |
| 1,9-Pyrazoloanthrone; |
Specifications
| 100 mg | |
| -30°C to -10°C | |
| C14H8N2O | |
| 1,9-Pyrazoloanthrone; | |
| SP600125, 99% | |
| ACPOUJIDANTYHO-UHFFFAOYSA-N | |
| 14,15-diazatetracyclo[7.6.1.0²,⁷.0¹³,¹⁶]hexadeca-1(15),2,4,6,9(16),10,12-heptaen-8-one | |
| 99% |
| Yellow to brown | |
| 129-56-6 | |
| 220.23 | |
| Soluble in DMSO at approx. 20mg/ml | |
| Solid | |
| O=C1C2=C3C(NN=C3C3=CC=CC=C13)=CC=C2 | |
| 220.23 |
Safety and Handling
Product Identifier
Signal Word
Hazard Category
Hazard Statement
Precautionary Statement
Supplemental information
- SP600125
Signal Word
- Warning
Hazard Category
- Serious eye damage/eye irritation Category 2
- Skin corrosion/irritation Category 2
- Specific target organ toxicity Category 3
Hazard Statement
- H315-Causes skin irritation.
- H319-Causes serious eye irritation.
- H335-May cause respiratory irritation.
Precautionary Statement
- P280-Wear protective gloves/protective clothing/eye protection/face protection.
- P302+P352-IF ON SKIN: Wash with plenty of water/soap.
- P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
- P312-Call a POISON CENTER/doctor/if you feel unwell.
- P332+P313-If skin irritation occurs: Get medical advice/attention.
- P337+P313-If eye irritation persists: Get medical advice/attention.
Supplemental information
- MIXTURE LIST-Contains : Anthra[1,9-cd]pyrazol-6(2H)-one
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