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Invitrogen™ Human Progesterone Receptor, Ligand Binding Domain, GST Tag Recombinant Protein

Recombinant Protein

Brand:  Invitrogen™ A15672

Product Code. 15430420

  • 10050.00 NOK / 600µg

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Description

Description

Progesterone receptor ligand binding domain (PR-LBD) is a 59.83 kDa recombinant human protein (amino acids 675-933) expressed as a glutathione-S-transferase (GST) fusion protein in baculovirus-infected insect cells. PR is expressed and purified in the absence of exogenous ligands, making it ideal for ligand binding and coregulator displacement studies. PR-LBD human recombinant protein is: , Flexible—use in your in-house assay or as part of our PolarScreen™ Competitor assays for a complete assay solution, Ready to use—active and tagged (with GST), Convenient—available in bulk sizes Contact us for bulk quantities or for assistance with other nuclear receptor assay needs, from assay development to library screening and beyond. Used in:PolarScreen™ Progesterone Receptor Competitor Assay, RedPolarScreen™ Progesterone Receptor Competitor Assay, Green, Protein Form: Ligand Binding Domain, Recombinant

The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. The PR mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. PR is found as a 94 kDa protein (Form A) or a 120 kDa protein (Form B) due to the use of alternative translation initiation sites. PR-B is the transcriptionally active form and is responsible for activating genes for the maintenance of the endometrium, maintenance of pregnancy, and inhibition of ovulation. PR-A is identical to PR-B except for a 165 amino acid deletion at the N-terminus. This deletion exposes a 140 amino acid inhibitory domain (ID) that acts as a repressor of steroid hormone transcriptional activity. In its inactive state, PgR forms a multiprotein complex which includes heat shock proteins and immunophins. Upon binding of progesterone hormone to its receptor, there is a conformational change that allows dimerization and binding of the receptor to progesterone response elements (PRE) sequences, resulting in activated transcription. A Null mutation in the PGR gene leads to pleiotrophic reproductive abnormalities.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

P06401
Kinase Assay
5241
0.6 mg
Progesterone Receptor
675-933
Human
GST-tag
Baculovirus
Ligand Binding Domain, Recombinant
See Label
proprietary buffer with no preservative
Human Progesterone Receptor, Ligand Binding Domain, GST Tag
9930019P03Rik; BB114106; ENSMUSG00000074510; LOW QUALITY PROTEIN: progesterone receptor; NR3C3; Nuclear receptor subfamily 3 group C member 3; p4 receptor; PGR; pot. alt. progesterone receptor; putative; PR; PR-A; PR-B; Progesterone receptor; progesterone receptor A; progesterone-receptor; putative form B; steroid hormone receptor; testicular progesterone receptor; unnamed protein product
PGR
Unconjugated
Recombinant
-80°C, Avoid Freeze/Thaw Cycles
Growth Factors & Receptors
Liquid
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