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Thermo Scientific™ Pierce™ Iminobiotin Agarose Product Code.: 11856734

Thermo Scientific™ Pierce™ Iminobiotin Agarose

Product Code. 11856734 Shop All Thermo Scientific Products
5 mL, 5mL
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Quantity:
5 mL
Unit Size:
5mL
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Product Code. 11856734

Brand: Thermo Scientific™ 20221

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This item is not returnable. View return policy

Agarose beads of immobilized biotin (and iminobiotin) to strongly (or reversibly) bind and remove (or purify) streptavidin or avidin proteins and conjugates from samples.

Thermo Scientific™ Pierce Iminobiotin and Biotin Resins provide for unusual affinity purification experiments involving clean-up or removal of streptavidin or avidin protein components.

Pierce Biotin Agarose and Iminobiotin Agarose are beaded agarose supports onto which biotin and iminobiotin moieties have been covalently immobilized. Typical avidin-biotin affinity procedures use immobilized avidin or streptavidin proteins to capture biotin-tagged molecules from a sample. Occasionally, however, the reverse situation arises in which immobilized biotin in needed to capture avidin or streptavidin components from a sample. These biotin and iminobiotin resins address this special situation.

Immobilized biotin binds avidin and streptavidin very strongly, making it appropriate for non-reversible binding applications. Immobilized iminobiotin is the guanido analog of biotin. The dissociation constant of the avidin-iminobiotin complex is pH dependent. At pH 9.5 to 11, the avidin-iminobiotin complex will bind tightly. At pH 4, the avidin-iminobiotin complex will dissociate. Thus, iminobiotin agarose can be used for situations requiring reversible binding and elution of avidin components.

Highlights:

  • Enable purification or removal of avidin or streptavidin samples
  • Resins are crosslinked beaded agarose onto which biotin or iminobiotin are covalently immobilized
  • Use Biotin Agarose for non-reversible binding (e.g., removal of avidin components from a sample)
  • Use Iminobiotin Agarose for reversible binding (e.g., non-denaturing purification of avidin)
TRUSTED_SUSTAINABILITY

Specifications

Description Pierce Iminobiotin Agarose
Content And Storage Upon receipt store at 4°C.
Product Line Pierce™
Quantity 5 mL
Target Streptavidin
Type Agarose
Stationary Phase Biotin Derivative
Format Bottle
Column Type Affinity, Agarose Resin

Certificates

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5 results found
Lot Number Certificate Type Date Product Code
Lot NumberAA405155 Certificate TypeCertificate of Analysis Date31/01/2025 Product Code20221
Lot NumberZG392939 Certificate TypeCertificate of Analysis Date07/08/2024 Product Code20221
Lot NumberYL382536 Certificate TypeCertificate of Analysis Date25/01/2024 Product Code20221
Lot NumberYD372938 Certificate TypeCertificate of Analysis Date05/05/2023 Product Code20221
Lot NumberXL364738 Certificate TypeCertificate of Analysis Date11/01/2023 Product Code20221

For Research Use Only. Not for use in diagnostic procedures.

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