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Thermo Scientific™ Pierce™ Hydroxylamine-HCl
NH2OH (CAS 7803-49-8) to cleave Asn-Gly peptide bonds or deprotect sulfhydryls following S-acetylthioacetate modification with SATA reagent.
Brand: Thermo Scientific™ 26103
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Description
Thermo Scientific™ Pierce Hydroxylamine-HCl has many uses, including to cleave Asn-Gly peptide bonds and to deprotect (expose) sulfhydryls for conjugation following modification with SATA and similar reagents.
Thermo Scientific™ Pierce Hydroxylamine-HCl has many uses, which include cleaving Asn-Gly peptide bonds and deprotecting (exposing) sulfhydryls on SATA-modified molecules for conjugation. Hydroxylamine·HCl is a strong reducing agent that is useful in biochemical crosslinking applications, including the deacetylation of SATA and chemical cleavage of EGS and Sulfo-EGS. Hydroxylamine converts carbonyl compounds (aldehydes and ketones) to their oxime derivatives in the presence of a weak base. Therefore, crosslinkers and other compounds that contain a carbonyl within their structure are cleavable with hydroxylamine-HCl.
Highlights:
- Exposes protected sulfhydryl groups on SATA-modified molecules
- Cleaves carbonyl-containing crosslinkers such as EGS
Reagent Properties:
- Chemical name: Hydroxylamine Hydrochloride
- Chemical formula: NH2OH·HCl
- Molecular weight: 69.49
- CAS Number: 5470-11-1
- Form: White crystals, free of foreign material
- Solubility: 10%
Specifications
| 5470-11-1 | |
| Pierce™ | |
| SATA | |
| Hydroxylamine Hydrochloride |
| Upon receipt store desiccated at room temperature. Product shipped at ambient temperature. | |
| Solid | |
| 25 g |
Safety and Handling
Product Identifier
Signal Word
Hazard Category
Hazard Statement
Precautionary Statement
Supplemental information
- Hydroxylamine Hydrochloride 25 Gm
Signal Word
- Danger
Hazard Category
- Acute toxicity Category 3
- Acute toxicity Category 4
- ACUTE AQUATIC Acute 1
- Carcinogenicity Category 2
- Serious eye damage/eye irritation Category 2
- Substances and mixtures corrosive to metals Category 1
- Skin corrosion/irritation Category 2
- Skin sensitiser Category 1
- Specific target organ toxicity after repeated exposure Category 2
Hazard Statement
- H290-May be corrosive to metals.
- H301-Toxic if swallowed.
- H312-Harmful in contact with skin.
- H315-Causes skin irritation.
- H317-May cause an allergic skin reaction.
- H319-Causes serious eye irritation.
- H351-Suspected of causing cancer.
- H373-May cause damage to organs.
- H400-Very toxic to aquatic life.
Precautionary Statement
- P201-Obtain special instructions before use.
- P264-Wash hands thoroughly after handling.
- P280-Wear protective gloves/protective clothing/eye protection/face protection.
- P301+P310-IF SWALLOWED: Immediately call a POISON CENTER/doctor /
- P302+P352-IF ON SKIN: Wash with plenty of water/soap.
- P390-Absorb spillage to prevent material damage.
- P406-Store in corrosive resistant/ container with a resistant inner liner.
- P501b-Dispose of contents/container in accordance with local/regional/national/international regulations.
Supplemental information
- MIXTURE LIST-Contains : Hydroxylamine, hydrochloride
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Product Title
For Research Use Only. Not for use in diagnostic procedures.
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