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Hygromycin B

Hygromycin B, CAS # 31282-04-9, is an aminoglycoside compound showing antibiotic activity that kills bacteria through the inhibition of protein synthesis. It also presents anthelmintic activity. | CAS: 31282-04-9 | C20H37N3O13 | 527.524 g/mol

Brand:  Thermo Scientific Alfa Aesar J60681.03

2250.00 NOK valid until 2025-06-30
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Quantity 1 g

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Product Code. 15493409

  • 2555.00 NOK / 1g
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Description

Description

An aminoglycoside antibiotic that kills bacteria by inhibiting protein synthesisHygromycin B is used for the selection and maintenance of prokaryotic and eukaryotic cells that contains the hygromycin resistance gene. This gene is frequently used as a selectable marker in research on plants. It stabilizes the transfer ribonucleic acid (tRNA)-ribosomal acceptor site, thereby inhibiting translocation. In addition to this, it serves as an aminoglycosidic antibiotic which inhibits protein synthesis.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Hygromycin is an aminoglycosidic compound that shows antibiotic activity. It is produced by Streptomyces hygroscopicus
  • Hygromycin acts against both prokaryotic and eukaryotic cells, having the ability to inhibit protein synthesis. It also stabilizes the transfer ribonucleic acid (tRNA)-ribosomal acceptor site, thereby inhibiting translocation. This compound prevents ribosome translocation during translation elongation by binding the 30S rRNA proximal to the ribosomal E, P, and A sites

Application

  • In clinical and plant research, this compound can be used as a marker to select and maintain prokaryotic and eukaryotic cells containing the hygromycin resistance gene
  • Hygromycin also presents an anthelmintic activity against nematode parasites of chickens
TRUSTED_SUSTAINABILITY
Specifications

Chemical Identifiers

31282-04-9
527.524
GRRNUXAQVGOGFE-BBMONYMYSA-N
(3'S,3aS,4S,4'S,5'R,6R,6'R,7R,7aS)-4-[(1R,2S,3R,5S,6S)-3-amino-2,6-dihydroxy-5-(methylamino)cyclohexyl]oxy-6'-[(1S)-1-amino-2-hydroxyethyl]-6-(hydroxymethyl)spiro[4,6,7,7a-tetrahydro-3aH-[1,3]dioxolo[4,5-c]pyran-2,2'-oxane]-3',4',5',7-tetrol
C20H37N3O13
MFCD06795479
134129613
CNC1CC(C(C(C1O)OC2C3C(C(C(O2)CO)O)OC4(O3)C(C(C(C(O4)C(CO)N)O)O)O)O)N

Specifications

Hygromycin B
31282-04-9
1 g
MFCD06795479
14,4852
GRRNUXAQVGOGFE-BBMONYMYSA-N
(3'S,3aS,4S,4'S,5'R,6R,6'R,7R,7aS)-4-[(1R,2S,3R,5S,6S)-3-amino-2,6-dihydroxy-5-(methylamino)cyclohexyl]oxy-6'-[(1S)-1-amino-2-hydroxyethyl]-6-(hydroxymethyl)spiro[4,6,7,7a-tetrahydro-3aH-[1,3]dioxolo[4,5-c]pyran-2,2'-oxane]-3',4',5',7-tetrol
134129613
Hygromycin B
Lyophilized Powder
Brown
C20H37N3O13
UN3462
Miscible with water,methanol,buffer solution and ethanol; Immiscible with less polar solvents.
CNC1CC(C(C(C1O)OC2C3C(C(C(O2)CO)O)OC4(O3)C(C(C(C(O4)C(CO)N)O)O)O)O)N
527.524
527.53
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Safety and Handling

Safety and Handling

Product Identifier
  • Hygromycin B

Signal Word
  • Danger

Hazard Category
  • Acute toxicity Category 1
  • Acute toxicity Category 2
  • Serious eye damage/eye irritation Category 1
  • Respiratory sensitiser Category 1
  • Skin sensitiser Category 1

Hazard Statement
  • H300-Fatal if swallowed.
  • H310-Fatal in contact with skin.
  • H317-May cause an allergic skin reaction.
  • H318-Causes serious eye damage.
  • H330-Fatal if inhaled.
  • H334-May cause allergy or asthma symptoms or breathing difficulties if inhaled.

Precautionary Statement
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P302+P352-IF ON SKIN: Wash with plenty of water/soap.
  • P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
  • P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P310-Immediately call a POISON CENTER/doctor/.
  • P330-Rinse mouth.

Supplemental information
  • MIXTURE LIST-Contains : Hygromycin B

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