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CSNK2A2 Rabbit anti-Human, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 10606-1-AP-150UL
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Description
Casein kinase II (CK2) is a constitutively active, ubiquitously expressed serine/threonine protein kinase that is thought to have a regulatory function in cell proliferation, cell differentiation and apoptosis. CK2 functions as a tetrameric complex consisting of two regulatory beta-subunits and two catalytic units (alpha and alpha′) in a homomeric or heteromeric conformation. Whilst the alpha- and alpha′-subunits are catalytically identical, proteins that regulate CK2, such as cdc2 and Hsp90, preferentially bind to the alpha and not the alpha′-subunit. CK2 can phosphorylate a number of key intracellular signaling proteins implicated in tumor suppression (p53 and PTEN) and tumorigenesis (myc, jun, NF-kappaB). CK2 is also thought to influence Wnt signaling via beta-catenin phosphorylation and the PI 3-K signaling pathway via the phosphorylation of Akt.Specifications
| CSNK2A2 | |
| Polyclonal | |
| Unconjugated | |
| CSNK2A2 | |
| Casein kinase II subunit alpha, CK II alpha, CK2A2, CSNK2A1, CSNK2A2 | |
| Rabbit | |
| Antigen Affinity Chromatography | |
| RUO | |
| 1459 | |
| -20°C | |
| Liquid |
| Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot | |
| 0.25 mg/mL | |
| PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 | |
| P19784 | |
| CSNK2A2 | |
| CSNK2A2 Fusion Protein Ag0877 | |
| 150 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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