missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Cell Culture Media, Supplements, and Reagents
  4. Cell Culture Reagents, Antibiotics and Supplements
  5. Antibiotics
  6. Bleomycin sulfate
  7. 15483439

Bleomycin sulfate

Bleomycin sulfate, CAS # 9041-93-4, is a glycopeptide compound with antibiotic activity isolated from Streptomyces verticillus. It also exhibits anticancer activity. | CAS: 9041-93-4 | C55H85N17O25S4 | 1512.619 g/mol

Brand:  Thermo Scientific Alfa Aesar J60727.MA

4518.00 NOK valid until 2025-06-30
Use promo code "24108" to get your promotional price.


Quantity 10 mg

 View more versions of this product

Product Code. 15483439

  • 5130.00 NOK / 10mg
Nurture Your Progress
Use promo code 24108 at checkout
View Available Promotions

Please to purchase this item. Need a web account? Register with us today!

This item is not returnable. View return policy

Description

Description

Bleomycin sulfate is used as a glycopeptide antibiotic. It is capable of inducing oxidative cleavage of the DNA backbone, leading to apoptosis and also degrades RNA, and has been reported to display selectivity for RNA over DNA. Bleomycin acts as a sclerosing agent.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Bleomycin sulfate was initially isolated from Streptomyces verticillus. It is a glycopeptide compound with antibiotic activity
  • It has the ability to induce oxidative cleavage of the DNA backbone, leading to apoptosis
  • Bleomycin sulfate can form a complex with iron that reduces oxygen to superoxide and hydroxyl radicals. These reactive oxygen species can cause single- and double-stranded breaks in DNA as well as promote carbohydrate oxidation, lipid peroxidation, and alterations in prostaglandin synthesis and degradation

Application

  • It can be used to inhibit DNA metabolism and slow or stop cell growth. This property explains its anticancer activity
  • Bleomycin sulfate can also be used to degrade RNA as it is more selective to RNA than DNA
  • Local injections of bleomycin sulfate in mouse models can induce sclerotic skin mimicking scleroderma
  • In laboratory research, bleomycin is used to induce pulmonary fibrosis in mice
TRUSTED_SUSTAINABILITY
Specifications

Chemical Identifiers

9041-93-4
1512.619
WUIABRMSWOKTOF-UHFFFAOYSA-N
[2-[2-[2-[[6-amino-2-[3-amino-1-[(2,3-diamino-3-oxopropyl)amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl]amino]-3-[[5-[[1-[2-[4-[4-(3-dimethylsulfoniopropylcarbamoyl)-1,3-thiazol-2-yl]-1,3-thiazol-2-yl]ethylamino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-hyd
C55H85N17O25S4
MFCD00070310
131664136
CC1=C(N=C(N=C1N)C(CC(=O)N)NCC(C(=O)N)N)C(=O)NC(C(C2=CN=CN2)OC3C(C(C(C(O3)CO)O)O)OC4C(C(C(C(O4)CO)O)OC(=N)[O-])O)C(=O)NC(C)C(C(C)C(=O)NC(C(C)O)C(=O)NCCC5=NC(=CS5)C6=NC(=CS6)C(=O)NCCC[S+](C)C)O.OS(=O)(=O)O

Specifications

Bleomycin Sulfate
9041-93-4
10 mg
MFCD00070310
Soluble in water or DMSO
CC1=C(N=C(N=C1N)C(CC(=O)N)NCC(C(=O)N)N)C(=O)NC(C(C2=CN=CN2)OC3C(C(C(C(O3)CO)O)O)OC4C(C(C(C(O4)CO)O)OC(=N)[O-])O)C(=O)NC(C)C(C(C)C(=O)NC(C(C)O)C(=O)NCCC5=NC(=CS5)C6=NC(=CS6)C(=O)NCCC[S+](C)C)O.OS(=O)(=O)O
1512.619
Bleomycin sulfate
Powder
White
C55H85N17O25S4
14,1318
WUIABRMSWOKTOF-UHFFFAOYSA-N
[2-[2-[2-[[6-amino-2-[3-amino-1-[(2,3-diamino-3-oxopropyl)amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl]amino]-3-[[5-[[1-[2-[4-[4-(3-dimethylsulfoniopropylcarbamoyl)-1,3-thiazol-2-yl]-1,3-thiazol-2-yl]ethylamino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-hyd
131664136
Product Suggestions

Product Suggestions

Videos
Safety and Handling

Safety and Handling

Product Identifier
  • Bleomycin sulfate

Signal Word
  • Danger

Hazard Category
  • Carcinogenicity Category 2
  • Germ cell mutagenicity Category 1B
  • Reproductive toxicity Category 2

Hazard Statement
  • H340-May cause genetic defects.
  • H351-Suspected of causing cancer.
  • H361d-Suspected of damaging the unborn child.

Precautionary Statement
  • P201-Obtain special instructions before use.
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P308+P313-IF exposed or concerned: Get medical advice/attention.

Supplemental information
  • MIXTURE LIST-Contains : Bleomycin, sulfate (salt)

SDS Documents

Documents

Certificates
Promotions

Promotions

Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Thank You! Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.