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  6. Thermo Scientific Chemicals 4-Epitetracycline hydrochloride, can be used as a secondary standard

Thermo Scientific Chemicals 4-Epitetracycline hydrochloride, can be used as a secondary standard

4-Epitetracycline hydrochloride, CAS # 23313-80-6, is a degradation product of tetracycline that shows antibiotic activity and can induce the protein biosynthesis inhibition.

289.13€ - 993.95€

Chemical Identifiers

CAS 23313-80-6
Molecular Formula C22H24N2O8·HCl
Molecular Weight (g/mol) 480.89
MDL Number MFCD00865028
InChI Key YCIHPQHVWDULOY-DXDJYCPMSA-N
Synonym 4-epitetracycline hydrochloride, epitetracycline hydrochloride, 4-epi-tetracycline hydrochloride, quatrimycin hydrochloride, epitetracycline hcl, unii-i7c3edl2yg, i7c3edl2yg, epitetracycline hydrochloride usp, 4r,4as,5as,6s,12as-4-dimethylamino-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride
PubChem CID 54686189
IUPAC Name (4R,4aS,5aS,6S,12aR)-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide;hydrochloride
SMILES CC1(C2CC3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.Cl
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Thermo Scientific Chemicals
233121000 		100 mg Glass bottle
289.13€
100mg
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Thermo Scientific Chemicals
233125000 		500 mg Glass bottle
993.95€
500mg
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Description

Description

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • 4-Epitetracycline hydrochloride is a metabolite derived from the degradation of tetracycline compounds and has been shown to display antibiotic activity
  • This compound blocks protein synthesis by binding to the 30S ribosomal subunit and interfering with the binding of aminoacyl-tRNA to the mRNA-ribosome complex

Applications

  • This semi-synthesized compound derived from actinomycetes can decrease the activity of the Tet repressor effector in animal models
  • In vivo experiments revealed that 4-epitetracycline hydrochloride can induce a toxic response
Specifications

Chemical Identifiers

23313-80-6
480.89
YCIHPQHVWDULOY-DXDJYCPMSA-N
54686189
CC1(C2CC3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.Cl
C22H24N2O8·HCl
MFCD00865028
4-epitetracycline hydrochloride, epitetracycline hydrochloride, 4-epi-tetracycline hydrochloride, quatrimycin hydrochloride, epitetracycline hcl, unii-i7c3edl2yg, i7c3edl2yg, epitetracycline hydrochloride usp, 4r,4as,5as,6s,12as-4-dimethylamino-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride
(4R,4aS,5aS,6S,12aR)-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide;hydrochloride

Specifications

23313-80-6
Yellow
80% min. (as is,calculated)
MFCD00865028
4-epitetracycline hydrochloride, epitetracycline hydrochloride, 4-epi-tetracycline hydrochloride, quatrimycin hydrochloride, epitetracycline hcl, unii-i7c3edl2yg, i7c3edl2yg, epitetracycline hydrochloride usp, 4r,4as,5as,6s,12as-4-dimethylamino-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride
YCIHPQHVWDULOY-DXDJYCPMSA-N
(4R,4aS,5aS,6S,12aR)-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide;hydrochloride
54686189
≥97.0% Total Base (on anhydrous substance), ≥80 wt% (as is, calculated) (HPLC)
4-Epitetracycline hydrochloride
217.0°C
Authentic
C22H24N2O8·HCl
− 322.00
Solubility in water: 100g/L. Other solubilities: 100g/L methanol
CC1(C2CC3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.Cl
480.89
480.89
Fine Crystalline Powder
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Safety and Handling

Safety and Handling

GHS H Statement:
Causes serious eye irritation.
Suspected of damaging the unborn child.

GHS P Statement:
Use personal protective equipment as required.
Wear protective gloves/protective clothing/eye protection/face protection.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.

GHS Signal Word: Warning

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Product Identifier
  • 4-Epitetracycline hydrochloride

Signal Word
  • Warning

Hazard Category
  • Serious eye damage/eye irritation Category 2
  • Reproductive toxicity Category 2

Hazard Statement
  • H361d-Suspected of damaging the unborn child.
  • H319-Causes serious eye irritation.

Precautionary Statement
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

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RUO – Research Use Only

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